PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Amino-PEG24-Boc
0 ImagesCat. No.: HY-140199CAS No.: 2170987-96-7
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tert-Butyl (7-aminoheptyl)carbamate
0 ImagesCat. No.: HY-22391CAS No.: 99733-18-3Synonyms: tert-Butyl 2,8-diaminooctanoate
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Thiol-PEG8-acid
0 ImagesCat. No.: HY-130542CAS No.: 866889-02-3
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Bis-PEG13-NHS ester
0 ImagesBis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Fmoc-azetidine-3-carboxylic acid
0 ImagesFmoc-azetidine-3-carboxylic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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N3-PEG3-CH2COOH
0 ImagesSynonyms: PROTAC Linker 14N3-PEG3-CH2COOH (PROTAC Linker 14) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N3-PEG3-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
![tert-Butyl (6-aminospiro[3.3]heptan-2-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-20240.gif "Click to View tert-Butyl (6-aminospiro[3.3]heptan-2-yl)carbamate Product Detail")
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1-Boc-azetidine-3-carboxylic acid
0 Images1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]-
Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne
0 ImagesCat. No.: HY-140928CAS No.: 2241685-22-1Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Mal-PEG4-acid
0 ImagesCat. No.: HY-126961CAS No.: 518044-41-2
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DBCO-PEG3-NHS
0 ImagesDBCO-PEG3-NHS is a biochemical assay reagent, that can be used to chemically modify proteins and antibodies with an alkynyl (DBCO) or N-hydroxysuccinimide (NHS) ester group. DBCO-PEG3-NHS can be used as a linker in PROTAC synthesis or for drug delivery and the development of biosensors and diagnostic reagents.
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Boc-piperazine-benzoic acid
0 ImagesBoc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229).
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Boc-NH-PEG6-CH2CH2COOH
0 ImagesCat. No.: HY-W040244CAS No.: 882847-13-4Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Azido-PEG5-azide
0 ImagesAzido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate
![tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate](https://file.medchemexpress.com/product_pic/hy-42347.gif "Click to View tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate Product Detail")
0 ImagesCat. No.: HY-42347CAS No.: 120157-97-3
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3-Oxocyclobutane-1-carbonitrile
0 ImagesCat. No.: HY-W004195CAS No.: 20249-16-5
